Publications [#386197] of Rajendra A. Morey

Papers Published

1. Steele, N; Hussain, A; Sun, D; Russell, C; Huggins, AA; Davenport, ND; Disner, SG; Sponheim, SR; Straube, T; Hofmann, D; Lissek, S; Berg, H; Grupe, DW; Nitschke, JB; Davidson, RJ; Lanius, R; Densmore, M; Théberge, J; Neufeld, RWJ; Thomopoulos, SI; Thompson, PM; Morey, RA (2025). Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder.. Neuroimage Clin, 49, 103927. [doi]
   (last updated on 2026/01/10)

   Abstract:
   The thalamus exhibits widespread connectivity to the entire cortical mantle, yet distinct thalamic subregions possess unique connectivity profiles and functional roles. While the thalamus has been consistently implicated in posttraumatic stress disorder (PTSD), fine-grained investigations examining thalamic subregions and nuclei remain sparse. We examined how resting-state functional connectivity (RSFC) of thalamic nuclei with the cortex and large-scale brain networks may contribute to PTSD using high-resolution functional magnetic resonance imaging (fMRI) data from a multi-site dataset of PTSD cases and controls (n = 397). We show that the pulvinar nuclei exhibit weaker RSFC with sensorimotor and salience regions, while the medial geniculate nucleus (MGN) exhibits stronger RSFC with the sensorimotor cortex in PTSD. Greater PTSD severity correlated with weaker RSFC between both the pulvinar and mediodorsal thalamus and cortical sensory/motor regions in the frontal, parietal, and occipital lobes. We identified that the default mode network of PTSD participants had stronger RSFC with the mediodorsal thalamus, while the salience and somatosensory networks exhibited stronger RSFC with somatomotor thalamic nuclei. Fine-grained thalamic mapping is important for uncovering thalamocortical disruptions in PTSD. Thalamic RSFC shows a shift toward heightened subcortical sensory responsivity and diminished voluntary control and cognitive regulation in PTSD.