Publications [#277278] of Redford B. Williams

Journal Articles

1. Williams, RB; Lane, JD; Kuhn, CM; Melosh, W; White, AD; Schanberg, SM (1982). Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks.. Science (New York, N.Y.), 218(4571), 483-485. [7123248], [doi]
   (last updated on 2023/06/01)

   Abstract:
   Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle vasodilatation and more enhanced secretion of norepinephrine, epinephrine, and cortisol than Type B subjects. During sensory intake, Type A hyperresponsivity was found for testosterone and, among those subjects with a positive family history of hypertension, for cortisol. As a demonstration of combined cardiovascular, sympathetic nervous system, and neuroendocrine hyperresponsivity to specific cognitive tasks in Type A subjects, this study breaks ground in the search for mechanisms mediating the increased coronary disease risk among Type A persons.