Publications [#273394] of Richard S. Keefe

Journal Articles

1. Roitman, SE; Keefe, RS; Harvey, PD; Siever, LJ; Mohs, RC (1997). Attentional and eye tracking deficits correlate with negative symptoms in schizophrenia.. Schizophrenia Research, 26(2-3), 139-146. [doi]
   (last updated on 2024/01/01)

   Abstract:
   Thirty patients with a DSM-III-R diagnosis of schizophrenia were assessed for severity of schizophrenic symptoms using the Brief Psychiatric Rating Scale (BPRS) and were tested on a Continuous Performance Test (CPT) and a smooth pursuit eye tracking task. Negative symptoms were significantly correlated with eye tracking impairment (r = 0.43, p < 0.01) and CPT deficits (r = 0.67, p < 0.001), but performance on neither task was correlated with positive symptoms. CPT performance and eye tracking performance were modestly correlated with each other (r = 0.39, p < 0.01) and CPT performance was found to be a stronger predictor of negative symptoms than eye tracking performance. These data indicate that neurocognitive markers of vulnerability to schizophrenia are associated with negative rather than positive symptoms.