Publications [#273540] of Richard S. Keefe

Journal Articles

1. Siever, LJ; Silverman, JM; Horvath, TB; Klar, H; Coccaro, E; Keefe, RS; Pinkham, L; Rinaldi, P; Mohs, RC; Davis, KL (1990). Increased morbid risk for schizophrenia-related disorders in relatives of schizotypal personality disordered patients.. Archives of General Psychiatry, 47(7), 634-640. [doi]
   (last updated on 2024/01/01)

   Abstract:
   To evaluate whether probands from a clinical sample diagnosed as having DSM-III schizotypal and/or paranoid personality disorder have a familial relationship to the schizophrenia-related disorders, the morbid risk for schizophrenia-related disorders and other psychiatric disorders were evaluated in the first-degree relatives of patients with schizotypal and/or paranoid personality disorder and compared with the corresponding risk for these disorders in the first-degree relatives of patients with other non-schizophrenia-related personality disorders. The morbid risk for all schizophrenia-related disorders, and specifically for schizophrenia-related personality disorders, was significantly greater among the relatives of the probands with schizotypal and/or paranoid personality disorder than among the relatives of probands with other personality disorder. The morbid risk for other psychiatric disorders did not differ significantly between the first-degree relatives of the schizotypal/paranoid personality disorder and the other personality disorder control proband samples. These results suggest a specific familial association between schizophrenia-related disorders, particularly schizophrenia-related personality disorders, and clinically diagnosed schizotypal patients.