Research Interests for Ashutosh Chilkoti

Chilkoti's research focuses on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, patterned biomaterials, and targeted drug delivery.

Keywords:

Genetic engineering, Thermally responsive polypeptides, Elastin-like polypeptides, Protein-polymer conjugates, Stimulus responsive fusion proteins, Nonfouling surfaces, Thermally targeted drug delivery, Nanoparticle SPR sensors, Polymer brushes, Polypeptide tissue engineering scaffolds, Injectable biomaterials, Bionanomanufacturing

Areas of Interest:

Biomolecular materials
Biointerface Science

Representative Publications   (search)

1. Bellucci, JJ; Amiram, M; Bhattacharyya, J; McCafferty, D; Chilkoti, A, Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides., Angewandte Chemie (International ed. in English), vol. 52 no. 13 (March, 2013), pp. 3703-3708, WILEY-VCH Verlag, ISSN 1521-3773 [23424160], [doi]
2. McDaniel, JR; Bhattacharyya, J; Vargo, KB; Hassouneh, W; Hammer, DA; Chilkoti, A, Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation., Angewandte Chemie (International ed. in English), vol. 52 no. 6 (February, 2013), pp. 1683-1687, WILEY-VCH Verlag, ISSN 1521-3773 [23280697], [doi]
3. Amiram, M; Luginbuhl, KM; Li, X; Feinglos, MN; Chilkoti, A, Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control., Proceedings of the National Academy of Sciences of the United States of America, vol. 110 no. 8 (February, 2013), pp. 2792-2797, National Acad Sciences, ISSN 0027-8424 [23359691], [doi] [abs]
4. Hubbell, JA; Chilkoti, A, Chemistry. Nanomaterials for drug delivery., Science (New York, N.Y.), vol. 337 no. 6092 (July, 2012), pp. 303-305, American Association for the Advancement of Science, ISSN 0036-8075 [22822138], [doi]
5. Amiram, M; Quiroz, FG; Callahan, DJ; Chilkoti, A, A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers., Nat Mater, vol. 10 no. 2 (February, 2011), pp. 141-148, Nature Publishing Group, ISSN 1476-1122 [21258353], [doi] [abs]
6. Gao, W; Liu, W; Christensen, T; Zalutsky, MR; Chilkoti, A, In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation., Proc Natl Acad Sci U S A, vol. 107 no. 38 (September, 2010), pp. 16432-16437, National Acad Sciences, ISSN 0027-8424 [20810920], [doi] [abs]
7. Hucknall, A; Rangarajan, S; Chilkoti, A, In pursuit of zero: Polymer brushes that resist the adsorption of proteins, Advanced Materials, vol. 21 no. 23 (June, 2009), pp. 2441-2446, WILEY, ISSN 0935-9648 [doi] [abs]
8. MacKay, JA; Chen, M; McDaniel, JR; Liu, W; Simnick, AJ; Chilkoti, A, Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection, Nature Materials, vol. 8 no. 12 (2009), pp. 993-999, Nature Publishing Group, ISSN 1476-1122 [19898461], [doi] [abs]