Publications [#112930] of G Vann V. Bennett

Papers Published

1. VC Okoye, V Bennett, Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes., Science (New York, N.Y.), UNITED STATES, vol. 227 no. 4683 (January, 1985), pp. 169-71, ISSN 0036-8075
   (last updated on 2003/02/18)

   Abstract:
   Human erythrocyte band 3, a major membrane-spanning protein, was purified and incorporated into liposomes. These liposomes, at nanomolar concentrations of protein, inhibited invasion of human erythrocytes in vitro by the malaria parasite Plasmodium falciparum. Liposomes containing human band 3 were ten times more effective in inhibiting invasion than those with pig band 3 and six times more effective than liposomes containing human erythrocyte glycophorin. Liposomes alone or liposomes containing erythrocyte glycolipids did not inhibit invasion. These results suggest that band 3 participates in the invasion process in a step involving a specific, high-affinity interaction between band 3 and some component of the parasite.

   Keywords:
   Anion Exchange Protein 1, Erythrocyte • Attachment Sites, Microbiological* • Erythrocyte Membrane • Glycophorin • Humans • Liposomes • Lysogeny* • Malaria • Membrane Proteins • Plasmodium falciparum • metabolism • metabolism* • physiology • physiology*