Publications [#160595] of David Needham

Papers Published

1. J. A. Tashjian and M. W. Dewhirst and D. Needham and B. L. Viglianti, Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques, International Journal Of Hyperthermia, vol. 24 no. 1 (2008), pp. 79 -- 90, ISSN 0265-6736
   (last updated on 2009/08/04)

   Abstract:
   The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.