Publications [#55913] of David Needham

Papers Published

1. Evans, E. and Needham, D., ATTRACTION BETWEEN LIPID BILAYER MEMBRANES IN CONCENTRATED SOLUTIONS OF NONADSORBING POLYMERS: COMPARISON OF MEAN-FIELD THEORY WITH MEASUREMENTS OF ADHESION ENERGY., Macromolecules, vol. 21 no. 6 (1988), pp. 1822 - 1831
   (last updated on 2007/04/06)

   Abstract:
   The authors report direct measurements of the free energy potential for adhesion of synthetic lipid bilayers in aqueous solutions of dextran (polyglucose) over a wide range of volume fraction (0. 01-0. 1) and molecular weight. These polymer solutions are well-modeled by a Flory interaction parameter of 0. 43, characteristic of a 'good' solvent. Controlled assembly of two giant bilayer vesicles was used to evaluate the free energy potential for formation of adhesive contact. The adhesion energy for neutral (phosphatidylcholine) bilayers in 0. 1 M NaCl was found to steadily increase with polymer volume fraction - without any indication of a plateau - and with little dependence of polymer size.

   Keywords:
   POLYMERS - Solutions;LIPIDS - Adhesion;MEMBRANES - Materials;ADHESION - Measurements;