Publications [#64970] of Sidney A Simon

Papers Published

1. Fralix, T.A. and Ceckler, T.L. and Wolff, S.D. and Simon, S.A. and Balaban, R.S., Lipid bilayer and water proton magnetization transfer: effect of cholesterol, Magn. Reson. Med. (USA), vol. 18 no. 1 (1991), pp. 214 - 23
   (last updated on 2007/04/15)

   Abstract:
   Magnetization transfer was measured in aqueous dispersions of egg phosphatidylcholine (EPC) in the presence and absence of cholesterol. It was found that neither EPC bilayers nor cholesterol by themselves significantly exchanged magnetization with bulk water ¹H. However, as the concentration of cholesterol was increased, the pseudo-first-order magnetization exchange rate increased to a maximum value of ~1 s^-1. The cholesterol-induced ¹H magnetization exchange may be related either to longer correlation times of the lipid or to an increase in the number of water molecules associated with the bilayer. These results indicate that EPC-cholesterol bilayers exchange ¹H magnetization with bulk water. These results are consistent with lipid bilayer contributions to bulk water relaxation and magnetization transfer contrast in intact biological tissues

   Keywords:
   biological NMR;lipid bilayers;magnetisation;molecular biophysics;proton magnetic resonance;