Publications [#232213] of Stephen L Craig

Journal Articles

1. Chen, J; Körner, S; Craig, SL; Lin, S; Rudkevich, DM; Rebek, J, Chemical amplification with encapsulated reagents., Proceedings of the National Academy of Sciences of the United States of America, vol. 99 no. 5 (March, 2002), pp. 2593-2596, ISSN 0027-8424 [doi]
   (last updated on 2026/01/17)

   Abstract:
   Autocatalysis and chemical amplification are characteristic properties of living systems, and they give rise to behaviors such as increased sensitivity, responsiveness, and self-replication. Here we report a synthetic system in which a unique form of compartmentalization leads to nonlinear, autocatalytic behavior. The compartment is a reversibly formed capsule in which a reagent is sequestered. Reaction products displace the reagent from the capsule into solution and the reaction rate is accelerated. The resulting self-regulation is sensitive to the highly selective molecular recognition properties of the capsule.