Publications [#232223] of Stephen L Craig

Journal Articles

1. Craig, SL; Brauman, JI, Intramolecular microsolvation of S(N)2 transition states, Journal of the American Chemical Society, vol. 121 no. 28 (July, 1999), pp. 6690-6699, American Chemical Society (ACS) [doi]
   (last updated on 2026/01/16)

   Abstract:
   Introduction of an ω-substituent (CN, Cl, or OH) onto a primary n- alkyl chloride significantly enhances the rate of S(N)2 chloride exchange in the gas phase. Trends in reactivity suggest that the rate acceleration depends primarily on through-space solvation of the transition state, especially charge-dipole interactions. The potential energy surfaces and dynamics of these reactions are discussed.