Publications [#354742] of Stephen L Craig

Journal Articles

1. Razgoniaev, AO; Glasstetter, LM; Kouznetsova, TB; Hall, KC; Horst, M; Craig, SL; Franz, KJ, Single-Molecule Activation and Quantification of Mechanically Triggered Palladium-Carbene Bond Dissociation., Journal of the American Chemical Society, vol. 143 no. 4 (February, 2021), pp. 1784-1789 [doi]
   (last updated on 2026/01/17)

   Abstract:
   Metal-complexed N-heterocyclic carbene (NHC) mechanophores are latent reactants and catalysts for a range of mechanically driven chemical responses, but mechanochemical scission of the metal-NHC bond has not been experimentally characterized. Here we report the single-molecule force spectroscopy of ligand dissociation from a pincer NHC-pyridine-NHC Pd(II) complex. The force-coupled rate constant for ligand dissociation reaches 50 s^-1 at forces of approximately 930 pN. Experimental and computational observations support a dissociative, rather than associative, mechanism of ligand displacement, with rate-limiting scission of the Pd-NHC bond followed by rapid dissociation of the pyridine moiety from Pd.