Publications [#322617] of Ashutosh Chilkoti

Papers Published

1. Liu, J; Pang, Y; Bhattacharyya, J; Liu, W; Weitzhandler, I; Li, X; Chilkoti, A, Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug., Advanced healthcare materials, vol. 5 no. 15 (August, 2016), pp. 1868-1873 [doi]
   (last updated on 2024/04/24)

   Abstract:
   Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.