Center for Biomolecular and Tissue Engineering Center for Biomolecular and Tissue Engineering
Pratt School of Engineering
Duke University
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Harold P. Erickson, Professor of Cell Biology and Center for Biomolecular and Tissue Engineering

Harold P. Erickson
Contact Info:
Office Location:  367 Nanaline H Duke
Email Address: send me a message
Web Page:  http://faculty.duhs.duke.edu/faculty/info?pid=531

Education:

Ph.D.Johns Hopkins University1968
Specialties:

Contraception, Biofluid Mechanics

Representative Publications   (More Publications)

  1. M Osawa, HP Erickson, Inside-out Z rings--constriction with and without GTP hydrolysis., Molecular microbiology, vol. 81 no. 2 (July, 2011), pp. 571-9, ISSN 1365-2958 [doi]  [abs]
  2. CA Lemmon, T Ohashi, HP Erickson, Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility., The Journal of biological chemistry, vol. 286 no. 30 (July, 2011), pp. 26375-82, ISSN 1083-351X [doi]  [abs]
  3. Y Chen, HP Erickson, Conformational changes of FtsZ reported by tryptophan mutants., Biochemistry, vol. 50 no. 21 (May, 2011), pp. 4675-84, ISSN 1520-4995 [doi]  [abs]
  4. HP Erickson, DE Anderson, M Osawa, FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one., Microbiology and molecular biology reviews : MMBR, vol. 74 no. 4 (December, 2010), pp. 504-28, ISSN 1098-5557 [doi]  [abs]
  5. HP Erickson, M Osawa, Cell division without FtsZ--a variety of redundant mechanisms., Molecular microbiology, vol. 78 no. 2 (October, 2010), pp. 267-70, ISSN 1365-2958
  6. D Popp, M Iwasa, HP Erickson, A Narita, Y Maéda, RC Robinson, Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ., The Journal of biological chemistry, vol. 285 no. 15 (April, 2010), pp. 11281-9, ISSN 1083-351X [doi]  [abs]
  7. R Kenjale, G Meng, DL Fink, T Juehne, T Ohashi, HP Erickson, G Waksman, JW St Geme 3rd, Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter., Infection and immunity, vol. 77 no. 11 (November, 2009), pp. 4704-13, ISSN 1098-5522 [doi]  [abs]
  8. M Osawa, DE Anderson, HP Erickson, Curved FtsZ protofilaments generate bending forces on liposome membranes., The EMBO journal, vol. 28 no. 22 (November, 2009), pp. 3476-84, ISSN 1460-2075 [doi]  [abs]
  9. Y Chen, HP Erickson, FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis., Biochemistry, vol. 48 no. 28 (July, 2009), pp. 6664-73, ISSN 1520-4995 [doi]  [abs]
  10. HP Erickson, Modeling the physics of FtsZ assembly and force generation., Proceedings of the National Academy of Sciences of the United States of America, vol. 106 no. 23 (June, 2009), pp. 9238-43, ISSN 1091-6490 [doi]  [abs]
  11. T Ohashi, AM Augustus, HP Erickson, Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin., Biochemistry, vol. 48 no. 19 (May, 2009), pp. 4189-97, ISSN 1520-4995 [doi]  [abs]
  12. T Ohashi, HP Erickson, Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds., Matrix biology : journal of the International Society for Matrix Biology, vol. 28 no. 3 (April, 2009), pp. 170-5, ISSN 1569-1802 [doi]  [abs]
  13. D Popp, M Iwasa, A Narita, HP Erickson, Y Maéda, FtsZ condensates: an in vitro electron microscopy study., Biopolymers, vol. 91 no. 5 (May, 2009), pp. 340-50, ISSN 0006-3525 [doi]  [abs]
  14. HP Erickson, Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy., Biological procedures online, vol. 11 (2009), pp. 32-51, ISSN 1480-9222 [doi]  [abs]
  15. M Osawa, HP Erickson, Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings., Methods in enzymology, vol. 464 (2009), pp. 3-17, ISSN 1557-7988 [doi]  [abs]
  16. CA Sontag, H Sage, HP Erickson, BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly., PloS one, vol. 4 no. 9 (2009), pp. e7253, ISSN 1932-6203 [doi]  [abs]
  17. GE White, HP Erickson, The coiled coils of cohesin are conserved in animals, but not in yeast., PloS one, vol. 4 no. 3 (2009), pp. e4674, ISSN 1932-6203 [doi]  [abs]
  18. J Xu, E Bae, Q Zhang, DS Annis, HP Erickson, DF Mosher, Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin., PloS one, vol. 4 no. 1 (2009), pp. e4113, ISSN 1932-6203 [doi]  [abs]
  19. HP Erickson, Evolution of the cytoskeleton., BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 29 no. 7 (July, 2007), pp. 668-77, ISSN 0265-9247 [doi]  [abs]
  20. T Ohashi, SD Galiacy, G Briscoe, HP Erickson, An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins., Protein science : a publication of the Protein Society, vol. 16 no. 7 (July, 2007), pp. 1429-38, ISSN 0961-8368 [doi]  [abs]
  21. S Takahashi, M Leiss, M Moser, T Ohashi, T Kitao, D Heckmann, A Pfeifer, H Kessler, J Takagi, HP Erickson, R Fässler, The RGD motif in fibronectin is essential for development but dispensable for fibril assembly., The Journal of cell biology, vol. 178 no. 1 (July, 2007), pp. 167-78, ISSN 0021-9525 [doi]  [abs]
  22. -PDFs of most of my recent papers are available at
    http://www.cellbio.duke.edu/Faculty/Research/Erickson.html
  23. M Osawa, HP Erickson, FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli., Journal of bacteriology, vol. 188 no. 20 (October, 2006), pp. 7132-40, ISSN 0021-9193 [doi]  [abs]
  24. GE White, HP Erickson, Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins., Journal of structural biology, vol. 154 no. 2 (May, 2006), pp. 111-21, ISSN 1047-8477 [doi]  [abs]
  25. M Osawa, HP Erickson, Probing the domain structure of FtsZ by random truncation and insertion of GFP., Microbiology (Reading, England), vol. 151 no. Pt 12 (December, 2005), pp. 4033-43, ISSN 1350-0872 [doi]  [abs]
  26. T Ohashi, HP Erickson, Domain unfolding plays a role in superfibronectin formation., The Journal of biological chemistry, vol. 280 no. 47 (November, 2005), pp. 39143-51, ISSN 0021-9258 [doi]  [abs]
  27. Y Chen, HP Erickson, Rapid in vitro assembly dynamics and subunit turnover of FtsZ demonstrated by fluorescence resonance energy transfer., The Journal of biological chemistry, vol. 280 no. 23 (June, 2005), pp. 22549-54, ISSN 0021-9258 [doi]  [abs]
  28. SD Redick, J Stricker, G Briscoe, HP Erickson, Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity., Journal of bacteriology, vol. 187 no. 8 (April, 2005), pp. 2727-36, ISSN 0021-9193 [doi]  [abs]
  29. CA Sontag, JT Staley, HP Erickson, In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB., The Journal of cell biology, vol. 169 no. 2 (April, 2005), pp. 233-8, ISSN 0021-9525 [doi]  [abs]
  30. Y Chen, K Bjornson, SD Redick, HP Erickson, A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus., Biophysical journal, vol. 88 no. 1 (January, 2005), pp. 505-14, ISSN 0006-3495 [doi]  [abs]
  31. DE Anderson, FJ Gueiros-Filho, HP Erickson, Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins., Journal of bacteriology, vol. 186 no. 17 (September, 2004), pp. 5775-81, ISSN 0021-9193 [doi]  [abs]
  32. T Ohashi, HP Erickson, The disulfide bonding pattern in ficolin multimers., The Journal of biological chemistry, vol. 279 no. 8 (February, 2004), pp. 6534-9, ISSN 0021-9258 [doi]  [abs]
  33. J Stricker, HP Erickson, In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function., Journal of bacteriology, vol. 185 no. 16 (August, 2003), pp. 4796-805, ISSN 0021-9193  [abs]
  34. T Ohashi, DP Kiehart, HP Erickson, Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants., Journal of cell science, vol. 115 no. Pt 6 (March, 2002), pp. 1221-9, ISSN 0021-9533  [abs]
  35. J Stricker, P Maddox, ED Salmon, HP Erickson, Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching., Proceedings of the National Academy of Sciences of the United States of America, vol. 99 no. 5 (March, 2002), pp. 3171-5, ISSN 0027-8424 [doi]  [abs]
  36. HP Erickson, Stretching fibronectin., Journal of muscle research and cell motility, vol. 23 no. 5-6 (2002), pp. 575-80, ISSN 0142-4319  [abs]
  37. HP Erickson, Gamma-tubulin nucleation: template or protofilament?, Nature cell biology, vol. 2 no. 6 (June, 2000), pp. E93-6, ISSN 1465-7392 [doi]  [abs]
  38. SD Redick, DL Settles, G Briscoe, HP Erickson, Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis., The Journal of cell biology, vol. 149 no. 2 (April, 2000), pp. 521-7, ISSN 0021-9525  [abs]
  39. T Ohashi, DP Kiehart, HP Erickson, Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein., Proceedings of the National Academy of Sciences of the United States of America, vol. 96 no. 5 (March, 1999), pp. 2153-8, ISSN 0027-8424  [abs]
  40. T Ohashi, HP Erickson, Oligomeric structure and tissue distribution of ficolins from mouse, pig and human., Archives of biochemistry and biophysics, vol. 360 no. 2 (December, 1998), pp. 223-32, ISSN 0003-9861 [doi]  [abs]
  41. TE Melby, CN Ciampaglio, G Briscoe, HP Erickson, The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge., The Journal of cell biology, vol. 142 no. 6 (September, 1998), pp. 1595-604, ISSN 0021-9525  [abs]
  42. ET O'Brien, ED Salmon, HP Erickson, How calcium causes microtubule depolymerization., Cell motility and the cytoskeleton, vol. 36 no. 2 (1997), pp. 125-35, ISSN 0886-1544 [doi]  [abs]
  43. HP Erickson, DW Taylor, KA Taylor, D Bramhill, Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers., Proceedings of the National Academy of Sciences of the United States of America, vol. 93 no. 1 (January, 1996), pp. 519-23, ISSN 0027-8424  [abs]
  44. DJ Leahy, I Aukhil, HP Erickson, 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Cell, vol. 84 no. 1 (January, 1996), pp. 155-64, ISSN 0092-8674  [abs]
  45. HP Erickson, Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin., Proceedings of the National Academy of Sciences of the United States of America, vol. 91 no. 21 (October, 1994), pp. 10114-8, ISSN 0027-8424  [abs]
  46. HP Erickson, Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins., The Journal of cell biology, vol. 120 no. 5 (March, 1993), pp. 1079-81, ISSN 0021-9525
  47. DJ Leahy, WA Hendrickson, I Aukhil, HP Erickson, Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein., Science (New York, N.Y.), vol. 258 no. 5084 (November, 1992), pp. 987-91, ISSN 0036-8075  [abs]
  48. SH Northrup, HP Erickson, Kinetics of protein-protein association explained by Brownian dynamics computer simulation., Proceedings of the National Academy of Sciences of the United States of America, vol. 89 no. 8 (April, 1992), pp. 3338-42, ISSN 0027-8424  [abs]
  49. HP Erickson, Co-operativity in protein-protein association. The structure and stability of the actin filament., Journal of molecular biology, vol. 206 no. 3 (April, 1989), pp. 465-74, ISSN 0022-2836  [abs]
  50. RA Walker, ET O'Brien, NK Pryer, MF Soboeiro, WA Voter, HP Erickson, ED Salmon, Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies., The Journal of cell biology, vol. 107 no. 4 (October, 1988), pp. 1437-48, ISSN 0021-9525  [abs]
  51. WA Voter, HP Erickson, The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism., The Journal of biological chemistry, vol. 259 no. 16 (August, 1984), pp. 10430-8, ISSN 0021-9258  [abs]
  52. HP Erickson, JL Inglesias, A six-armed oligomer isolated from cell surface fibronectin preparations., Nature, vol. 311 no. 5983 (November, 1984), pp. 267-9, ISSN 0028-0836  [abs]
  53. WE Fowler, HP Erickson, Trinodular structure of fibrinogen. Confirmation by both shadowing and negative stain electron microscopy., Journal of molecular biology, vol. 134 no. 2 (October, 1979), pp. 241-9, ISSN 0022-2836
  54. HP Erickson, Microtubule surface lattice and subunit structure and observations on reassembly., The Journal of cell biology, vol. 60 no. 1 (January, 1974), pp. 153-67, ISSN 0021-9525  [abs]

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