Publications [#98457] of John H Sampson

Papers Published

1. PE Fecci, DA Mitchell, GE Archer, MA Morse, HK Lyerly, DD Bigner, JH Sampson, The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors., Journal of neuro-oncology, Netherlands, vol. 64 no. 1-2 , pp. 161-76, ISSN 0167-594X
   (last updated on 2006/06/06)

   Abstract:
   Despite advancements in therapeutic regimens, the prognosis remains poor for patients with malignant gliomas. Specificity has been an elusive goal for current modalities, but immunotherapy has emerged as a potential means of designing more tumor-specific treatments. Dendritic cells (DC) are the specialized antigen presenting cells of the immune system and have served now as a platform for therapeutic immunizations against such cancers as lymphoma, multiple myeloma, melanoma, prostate cancer, renal cell carcinoma, non-small cell lung carcinoma, colon cancer, and even malignant gliomas. DC-based immunizations offer a number of advantages over traditional immunotherapeutic approaches to brain tumors, approaches that have proved promising despite concerns over central nervous system immune privilege and glioma-mediated immunosuppression. The future success of clinical trials will depend on the optimization and standardizing of procedures for DC generation, loading, and administration.

   Keywords:
   Animals • Brain Neoplasms • Cancer Vaccines • Dendritic Cells • History, 20th Century • History, 21st Century • Humans • Immunotherapy* • history • methods • therapy* • transplantation*