Publications [#148460] of Bruce M. Klitzman

Papers Published

1. A Baccarani, K Yasui, KC Olbrich, A El-Sabbagh, S Kovach, KE Follmar, D Erdmann, LS Levin, JS Stamler, B Klitzman, MR Zenn, Efficacy of ethyl nitrite in reversing surgical vasospasm., Journal of reconstructive microsurgery, vol. 23 no. 5 (July, 2007), pp. 257-62, ISSN 0743-684X [doi]
   (last updated on 2013/07/01)

   Abstract:
   Vasospasm leading to thrombosis is a major cause of free flap failure. Flap blood flow may improve by application of vasodilating agents to the pedicle. The purpose of this study is to evaluate the effect of a novel S-nitrosylating agent, O-ethyl nitrite, on flap blood flow and pedicle vessels diameter in a rat model, after induction of vasospasm. Two hours after surgery, the arterial diameter was significantly (P < .05) dilated by treatment with O-ethyl nitrite, lidocaine, or lidocaine + O-ethyl nitrite. None of these treatments had a statistically significant effect on blood flow or venous diameter. Twenty-four hours following surgery, both O-ethyl nitrite- and lidocaine-treated groups had larger arteries than the control group (P < .05). The O-ethyl nitrite-treated animals also had significantly (P < .05) elevated blood flow compared with control animals, but lidocaine-treated animals did not demonstrate any improved flow at 24 hours. O-Ethyl nitrite may become clinically useful in microvascular surgery procedures.

   Keywords:
   Animals • Laser-Doppler Flowmetry • Male • Nitrites • Prodrugs • Rats • Rats, Inbred Strains • Regional Blood Flow • Vascular Diseases • Vasoconstriction • Vasodilator Agents • drug effects • drug therapy • pharmacology* • therapeutic use • therapeutic use*