Publications [#64523] of Bruce M. Klitzman

Papers Published

1. Wisniewski, Natalie and Rajamand, Neda and Reichert, William and Klitzman, Bruce and Ungerstedt, Urban, Metabolites at a biomaterial-tissue interface sampled by microdialysis - a comparison of the subcutaneous foreign body response in humans and rats over 8 days, Annals of Biomedical Engineering, vol. 28 no. SUPPL 1 (2000), pp. -19 -, Washington, WA, USA
   (last updated on 2007/04/15)

   Abstract:
   The purpose of this work was to study how closely the rat models the human subcutaneous (SQ) foreign body response. Polyamide microdialysis probes (CMA/Microdialysis; Solna, Sweden) were implanted subcutaneously in healthy human volunteers and in Sprague Dawley rats (n = 12 probes per group). Microdialysis samples were collected over 8 days and analyzed for glucose, lactate, pyruvate and glycerol content. Correpsonding blood samples were analyzed. Results showed significant differences in the microdialysate concentrations and 8 day trends in humans in rats.

   Keywords:
   Biomaterials;Tissue;Metabolites;Dialysis;Glucose;Glycerol;Blood;Immunology;