Publications [#232590] of Michael C. Fitzgerald

Journal Articles

1. Wu, Z; Ercole, F; FitzGerald, M; Perera, S; Riley, P; Campbell, R; Pham, Y; Rea, P; Sandanayake, S; Mathieu, MN; Bray, AM; Ede, NJ, Synthesis of tetrahydro-1,4-benzodiazepine-2-ones on hydrophilic polyamide SynPhase lanterns., Journal of combinatorial chemistry, vol. 5 no. 2 (March, 2003), pp. 166-171, ISSN 1520-4766 [doi]
   (last updated on 2026/01/15)

   Abstract:
   Solid-phase synthesis is greatly dependent on the solid support. Here, we report the use of a new hydrophilic grafted surface on SynPhase lanterns in solid-phase organic chemistry. A convenient and facile solid-phase synthesis of disubstituted 1,4-benzodiazepine-2-ones on polyamide SynPhase lanterns is described. The key step of the synthesis involved a reduction-cyclization of a nitroaryl methyl ester with a mixture of tin(II) chloride dihydrate and ammonium acetate in water and ethanol at elevated temperature to give the desired target compounds. A library of 21 disubstituted 1,4-benzodiazepine-2-ones was prepared.