Publications [#330247] of Michael J. Therien

Papers Published

1. Roy, P; Leblanc, Y; Ball, RG; Brideau, C; Chan, CC; Chauret, N; Cromlish, W; Ethier, D; Gauthier, JY; Gordon, R; Greig, G; Guay, J; Kargman, S; Lau, CK; O'Neill, G; Silva, J; Thérien, M; Van Staden, C; Wong, E; Xu, L; Prasit, P, A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles, Bioorganic and Medicinal Chemistry Letters, vol. 7 no. 1 (January, 1997), pp. 57-62, Elsevier BV [doi]
   (last updated on 2026/01/17)

   Abstract:
   A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. This lead to the discovery of L-768,277, a potent and selective COX-2 inhibitor that also demonstrated good in vivo activity.