Publications [#382098] of Tuan Vo-Dinh

Papers Published

1. Menozzi, L; Vu, T; Canning, AJ; Rawtani, H; Taboada, C; Abi Antoun, ME; Ma, C; Delia, J; Nguyen, VT; Cho, S-W; Chen, J; Charity, T; Xu, Y; Tran, P; Xia, J; Palmer, GM; Vo-Dinh, T; Feng, L; Yao, J, Three-dimensional diffractive acoustic tomography., Nat Commun, vol. 16 no. 1 (January, 2025), pp. 1149 [doi]
   (last updated on 2026/01/10)

   Abstract:
   Acoustically probing biological tissues with light or sound, photoacoustic and ultrasound imaging can provide anatomical, functional, and/or molecular information at depths far beyond the optical diffusion limit. However, most photoacoustic and ultrasound imaging systems rely on linear-array transducers with elevational focusing and are limited to two-dimensional imaging with anisotropic resolutions. Here, we present three-dimensional diffractive acoustic tomography (3D-DAT), which uses an off-the-shelf linear-array transducer with single-slit acoustic diffraction. Without jeopardizing its accessibility by general users, 3D-DAT has achieved simultaneous 3D photoacoustic and ultrasound imaging with optimal imaging performance in deep tissues, providing near-isotropic resolutions, high imaging speed, and a large field-of-view, as well as enhanced quantitative accuracy and detection sensitivity. Moreover, powered by the fast focal line volumetric reconstruction, 3D-DAT has achieved 50-fold faster reconstruction times than traditional photoacoustic imaging reconstruction. Using 3D-DAT on small animal models, we mapped the distribution of the biliverdin-binding serpin complex in glassfrogs, tracked gold nanoparticle accumulation in a mouse tumor model, imaged genetically-encoded photoswitchable tumors, and investigated polyfluoroalkyl substances exposure on developing embryos. With its enhanced imaging performance and high accessibility, 3D-DAT may find broad applications in fundamental life sciences and biomedical research.