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| Publications [#87699] of Virginia B Kraus
Papers Published
- AD Dragomir, VB Kraus, JB Renner, G Luta, A Clark, V Vilim, MC Hochberg, CG Helmick, JM Jordan, Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology.,
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, England, vol. 10 no. 9
(September, 2002),
pp. 687-91, ISSN 1063-4584
(last updated on 2007/11/29)
Abstract:
OBJECTIVE: To examine the cross-sectional relationship between serum cartilage oligomeric matrix protein (COMP) and hip and knee clinical signs and symptoms in a sample of adults without radiographic hip or knee osteoarthritis (OA). DESIGN: A total of 145 persons with available sera and no evidence of radiographic hip or knee OA (Kellgren-Lawrence grade 0) were randomly selected from the Caucasian participants of the Johnston County Osteoarthritis Project. COMP was quantified by a competitive ELISA assay with a monoclonal antibody 17-C10. Hip and knee clinical signs and symptoms were assessed by physical examination and interview, and their associations with Ln COMP analysed with general linear models. RESULTS: After adjustment for age, gender, body mass index (BMI), and other symptomatic joints, mean Ln COMP was statistically significantly higher among persons with hip-related clinical signs (P=0.018), among those with hip-related symptoms (P=0.046), and among individuals meeting American College of Rheumatology clinical criteria for hip OA (P=0.021). There were no statistically significant associations between any of the knee-related clinical signs and symptoms and Ln COMP. CONCLUSION: Serum COMP may be useful as a biomarker of pre-radiographic hip joint pathology; its utility as a biomarker of pre-radiographic knee joint pathology is unclear.
Keywords:
Aged • Aged, 80 and over • Cartilage, Articular • Enzyme-Linked Immunosorbent Assay • Extracellular Matrix Proteins • Female • Glycoproteins • Hip Joint • Humans • Knee Joint • Male • Middle Aged • blood* • pathology • pathology* • radiography
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