Publications [#285321] of Amanda Hargrove

Journal Articles

1. Raskatov, JA; Hargrove, AE; So, AY; Dervan, PB, Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear., Journal of the American Chemical Society, vol. 134 no. 18 (May, 2012), pp. 7995-7999, ISSN 0002-7863 [doi]
   (last updated on 2024/12/31)

   Abstract:
   The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provide a foundation for design of DNA binding Py-Im polyamides to be tested in vivo.