Publications [#339782] of Amanda Hargrove

Journal Articles

1. Patwardhan, NN; Cai, Z; Newson, CN; Hargrove, AE, Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA., Organic & biomolecular chemistry, vol. 17 no. 7 (February, 2019), pp. 1778-1786 [doi]
   (last updated on 2024/12/31)

   Abstract:
   A prominent hurdle in developing small molecule probes against RNA is the relative scarcity of general screening methods. In this study, we demonstrate the application of a fluorescent peptide displacement assay to screen small molecule probes against four different RNA targets. The designed experimental protocol combined with statistical analysis provides a fast and convenient method to simultaneously evaluate small molecule libraries against different RNA targets and classify them based on affinity and selectivity patterns.