Publications [#234847] of Benjamin J. Wiley

Journal Articles

1. Martinez, AW; Phillips, ST; Wiley, BJ; Gupta, M; Whitesides, GM, FLASH: a rapid method for prototyping paper-based microfluidic devices., Lab on a chip, vol. 8 no. 12 (December, 2008), pp. 2146-2150, ISSN 1473-0197 [doi]
   (last updated on 2026/01/15)

   Abstract:
   This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of microfluidic devices in paper. Paper-based microfluidic devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 microm in width and 70 microm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based microfluidic devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based microfluidic devices in regions where the technological support for conventional photolithography is not available.