Publications [#179145] of Christopher R Kelsey

Papers Published

1. J Ma, J Zhang, S Zhou, JL Hubbs, RJ Foltz, DR Hollis, KL Light, TZ Wong, CR Kelsey, LB Marks, Regional lung density changes after radiation therapy for tumors in and around thorax., International journal of radiation oncology, biology, physics, vol. 76 no. 1 (January, 2010), pp. 116-22, ISSN 1879-355X [doi]
   (last updated on 2010/09/14)

   Abstract:
   PURPOSE: To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors. METHODS AND MATERIALS: Between 1991 and 2004, 118 patients with interpretable pre- and post-radiation therapy (RT) chest computed tomography (CT) scans were evaluated. Changes in regional lung density were related to regional dose to define a dose-response curve (DRC) for RT-induced lung injury using three-dimensional planning tools and image fusion. Multiple post-RT follow-up CT scans were evaluated by fitting linear-quadratic models of density changes on dose with time as the covariate. Various patient- and treatment-related factors were examined as well. RESULTS: There was a dose-dependent increase in regional lung density at nearly all post-RT follow-up intervals. The population volume-weighted changes evolved over the initial 6-month period after RT and reached a plateau thereafter (p < 0.001). On univariate analysis, patient age greater than 65 years (p = 0.003) and/or the use of pre-RT surgery (p < 0.001) were associated with significantly greater changes in CT density at both 6 and 12 months after RT, but the magnitude of this effect was modest. CONCLUSIONS: There appears to be a temporal nature for the dose-dependent increases in lung density. Nondosimetric clinical factors tend to have no, or a modest, impact on these changes.

   Keywords:
   Adult • Aged • Aged, 80 and over • Algorithms • Analysis of Variance • Breast Neoplasms • Dose-Response Relationship, Radiation • Female • Follow-Up Studies • Humans • Linear Models • Lung • Lung Neoplasms • Lymphoma • Male • Middle Aged • Prospective Studies • Radiation Injuries • Radiotherapy Planning, Computer-Assisted • Tomography, X-Ray Computed • Young Adult • radiation effects* • radiography • radiography* • radiotherapy