Publications [#99290] of Gayathri R Devi

Papers Published

1. G Devi, K Marder, PW Schofield, MX Tang, Y Stern, R Mayeux, Validity of family history for the diagnosis of dementia among siblings of patients with late-onset Alzheimer's disease., Genetic epidemiology, vol. 15 no. 3 (1998), pp. 215-23, ISSN 0741-0395 [doi]
   (last updated on 2010/08/09)

   Abstract:
   We examined 180 siblings of 127 probands with probable or possible Alzheimer's dementia (AD) in a family study of AD. The overall sensitivity of a simple family history questionnaire was 64% and the specificity was 84%. Sensitivity improved 90-100% with minimal decline in specificity when we considered clinic-based vs. population survey patients. Higher education among informants and the availability of a spouse or a sibling as informant significantly increased sensitivity. Awareness of such factors may improve the yield of the family history in AD using a simple questionnaire.

   Keywords:
   Age of Onset • Aged • Aged, 80 and over • Alzheimer Disease • Demography • Female • Genetic Testing • Humans • Male • Medical History Taking • Middle Aged • Questionnaires • Reproducibility of Results • Sensitivity and Specificity • genetics* • methods*