Publications [#210162] of Mark W. Dewhirst

Papers Published

1. AS Betof, MW Dewhirst, LW Jones, Effects and potential mechanisms of exercise training on cancer progression: A translational perspective., Brain, behavior, and immunity (May, 2012), ISSN 1090-2139 [doi]
   (last updated on 2012/10/26)

   Abstract:
   Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.