Publications [#63178] of Mark W. Dewhirst

Papers Published

1. Oleson, J.R. and Samulski, T.V. and Leopold, K.A. and Clegg, S.T. and Dewhirst, M.W. and Dodge, R.K. and George, S.L., Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 25 no. 2 (1993), pp. 289 - 97
   (last updated on 2007/04/14)

   Abstract:
   The authors have calculated the time for isoeffective treatments with T₉₀=43°C and T₅₀=43°C, respectively, using published thermal isoeffective dose formulae. The purpose of these calculations was to determine the sensitivity of treatment outcome to variations in thermal isoeffective dose. It is concluded that for regimens of 5 to 10 hyperthermia treatments, improvements in median T₉₀ (superficial tumors) and T₅₀ (deep tumors) parameters by 1.2-1.5°C could result in response rates high enough (compared to radiotherapy alone) to justify Phase III trials. A similar improvement in response rates would require an increase in overall duration of treatment by a factor of 3 to 5. This would be difficult to achieve while also avoiding thermal tolerance induction. Achieving these temperature goals may be possible with improvements in hyperthermia technology. Alternatively, there may be ways to increase the sensitivity of cells to temperatures that can be achieved currently, such as pH reduction or chemosensitization

   Keywords:
   biothermics;patient treatment;