Publications [#63219] of Mark W. Dewhirst

Papers Published

1. Dewhirst, M.W. and Oliver, R. and Tso, C.Y. and Gustafson, C. and Secomb, T. and Gross, J.F., Heterogeneity in tumor microvascular response to radiation, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 18 no. 3 (1990), pp. 559 - 68
   (last updated on 2007/04/14)

   Abstract:
   Tumor microvascular hemodynamics and morphologies were studied using the R3230 Ac mammary adenocarcinoma transplanted in a dorsal flap window chamber of the Fisher-344 rat. Measurements were made before and after (at 24 and 72 hr) 5-Gy radiation exposure to assess microvascular changes and to explore possible explanations for the heterogeneity of the effect. There was considerable heterogeneity between tumors prior to radiation. Vascular densities ranged from 67 to 3000 vessels/mm³ and median vessel diameters from 22 to 85 μm. Pretreatment perfusion values varied by a factor of six. In irradiated tumors, conjoint increases in both vacular density and perfusion occurred in most tumors, although the degree of change was variable from one individual to the next. The degree of change in density was inversely related to median pretreatment diameter. Relative change in flow, as predicted by morphometric measurements, overestimated observed changes in flow measured hemodynamically. These results support that heterogeneity in tumor vascular effects from radiation are somewhat dependent on pretreatment morphology as well as relative change in morphology

   Keywords:
   biological effects of ionising radiation;biorheology;