Publications [#63244] of Mark W. Dewhirst

Papers Published

1. Prescott, D.M. and Charles, H.C. and Sostman, H.D. and Dodge, R.K. and Thrall, D.E. and Page, R.L. and Tucker, J.A. and Harrelson, J.M. and Leopold, K.A. and Oleson, J.R. and Dewhirst, M.W., Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 28 no. 2 (1994), pp. 415 - 23
   (last updated on 2007/04/14)

   Abstract:
   Twenty-one human patients and 10 canine patients with soft tissue sarcomas treated with preoperative hyperthermia and radiation had a series of magnetic resonance imaging and phosphorus spectroscopy studies done. To address the goals for both the human and canine populations, changes in mean T₂ relaxation times, pH, and various phosphometabolite ratios from the pretreatment (Study 1) to the post first hyperthermia study (Study 2) were correlated with treatment outcome; pretreatment magnetic resonance parameters and changes in magnetic resonance parameters (Study 2-Study 1) were compared with various cumulative thermal descriptors; and thermal descriptors of the first hyperthermia were compared with changes in magnetic resonance phosphometabolite ratios. The results indicate that changes in magnetic resonance parameters early during therapy may be predictive of treatment outcome. Pretreatment and changes in magnetic resonance parameters appear to predict how well a tumor will be heated during hyperthermia. Magnetic resonance spectroscopy also appears to be a useful tool to study the effects of various thermal doses on tumor metabolic status

   Keywords:
   biomedical NMR;biothermics;nuclear magnetic resonance spectroscopy;patient monitoring;radiation therapy;