Publications [#232445] of Emily R. Derbyshire

Journal Articles

1. Martin, NI; Derbyshire, ER; Marletta, MA, Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1., Bioorganic & medicinal chemistry letters, vol. 17 no. 17 (September, 2007), pp. 4938-4941, ISSN 0960-894X [17587571], [doi]
   (last updated on 2024/12/31)

   Abstract:
   Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.