Publications [#232462] of Emily R. Derbyshire

Journal Articles

1. Carr, G; Derbyshire, ER; Caldera, E; Currie, CR; Clardy, J, Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp., Journal of natural products, vol. 75 no. 10 (October, 2012), pp. 1806-1809 [23025282], [doi]
   (last updated on 2024/12/31)

   Abstract:
   Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.