Publications [#234194] of Eric J. Toone

Journal Articles

1. Mori, T; Hatano, K; Matsuoka, K; Esumi, Y; Toone, EJ; Terunuma, D, Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose, Tetrahedron, vol. 61 no. 11 (March, 2005), pp. 2751-2760, Elsevier BV [doi]
   (last updated on 2026/01/13)

   Abstract:
   The mannose monosaccharide derivative, acetylthiopropyl 2,3,4,6-tetra-O-acetyl-α-d-mannopyranoside (Man), and the mannobiose derivative, acetylthiopropyl 2,4,6-tri-O-acetyl-3-O-(2′,3′,4′, 6′-tetra-O-acetyl-α-d-mannopyranosyl)-α-d-mannopyranoside (α-1,3-Man), were synthesized respectively. These mannose derivatives were introduced into carbosilane dendrimer scaffolds of the zero and first generations. As a result, six carbosilane dendrimers were functionalized by Man and α-1,3-Man. Isothermal titration microcalorimetry was done to determine binding assay between mannose moieties of carbosilane dendrimer and concanavalin A. It was found that carbosilane dendrimers bound more efficiently to concanavalin A than free mannose (Me-α-Man) and mannobiose (Me-α-1,3-Man). © 2005 Elsevier Ltd. All rights reserved.