Publications [#60958] of George A. Truskey

Papers Published

1. Rinker, K.D. and Prabhakar, V. and Osborn, E.A. and Truskey, G.A., Effect of fluid viscosity and erythrocytes on monocyte adhesion, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), vol. vol.1 (1999), pp. 59 vol.1 -, Atlanta, GA, USA [IEMBS.1999.802085]
   (last updated on 2007/04/12)

   Abstract:
   Monocyte recruitment to vascular endothelium is a key event linked to the development of atherosclerosis. Adhesion is influenced by many parameters including local fluid dynamics, intracellular collisions, and adhesion receptor expression. Elevated medium viscosity as well as the presence of erythrocytes in monocyte-containing media was found to increase monocyte adhesion to vascular endothelial cells. By comparing monocyte rolling velocities and arrest durations in fluids of differing viscosities at the same shear rates, monocyte adhesion was found to be shear stress dependent. Supplementation of the monocyte-containing medium with red blood cells increased tethering frequencies to a greater extent than the effect of elevated viscosity alone

   Keywords:
   adhesion;blood vessels;cellular biophysics;haemodynamics;haemorheology;viscosity;