Publications [#198261] of Gregory M Palmer

Papers Published

1. HL Fu, B Yu, JY Lo, GM Palmer, TF Kuech, N Ramanujam, A low-cost, portable, and quantitative spectral imaging system for application to biological tissues., Optics express, vol. 18 no. 12 (June, 2010), pp. 12630-45, ISSN 1094-4087
   (last updated on 2011/12/01)

   Abstract:
   The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').

   Keywords:
   Computer Simulation • Imaging, Three-Dimensional • Optical Phenomena • Phantoms, Imaging* • Spectrum Analysis • economics* • methods*