Publications [#279848] of Farshid Guilak

Papers Published

1. Upton, ML; Chen, J; Guilak, F; Setton, LA, Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1 (2002), pp. 438-439, Houston, TX, USA [IEMBS.2002.1136884]
   (last updated on 2019/06/30)

   Abstract:
   The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

   Keywords:
   biological tissues;biomechanics;genetics;orthopaedics;proteins;