Publications [#113197] of Harold P. Erickson

Papers Published

1. DA Siever, HP Erickson, Extracellular annexin II., The international journal of biochemistry & cell biology, ENGLAND, vol. 29 no. 11 (November, 1997), pp. 1219-23, ISSN 1357-2725
   (last updated on 2009/02/12)

   Abstract:
   Annexin II belongs to a family of calcium-dependent, phospholipid binding proteins. Annexin II was first identified as an intracellular protein and attributed intracellular functions. Although it lacks a signal peptide and its mechanism of secretion is unknown, extracellular annexin II has recently been found in several tissues as both soluble and membrane-bound protein. Cell-surface annexin II has been identified as a receptor for a number of polypeptide ligands. Extracellular annexin II may be important in several biological processes, such as fibrinolysis, cell adhesion, ligand-mediated cell signaling and virus infection. These processes provide several possibilities for therapeutic approaches targeting extracellular annexin II, and future research should further illuminate the biology of this molecule.

   Keywords:
   Annexin A2 • Cell Adhesion • Humans • Ligands • Membrane Proteins • Models, Molecular • Plasminogen Activators • Signal Transduction • Tenascin • chemistry • physiology • physiology* • therapeutic use