Publications [#80866] of Russell P. Hall III

Papers Published

1. P Szabolcs, M Reese, KB Yancey, RP Hall, J Kurtzberg, Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease., Bone marrow transplantation, vol. 30 no. 5 (September, 2002), pp. 327-9, ISSN 0268-3369 [doi]
   (last updated on 2013/05/16)

   Abstract:
   In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after unrelated cord blood transplantation. Monitoring the BP-specific circulating antibodies and CD25-expressing activated T lymphocyte subset led us to combine anti-CD20 (Rituximab) mediated B cell ablation with anti-CD25 (Daclizumab) therapy to block CD4(+) T cell help. Complete clinical and serologic response was achieved within 4 weeks of initiation of therapy allowing global immunosuppression to be dramatically reduced.

   Keywords:
   Antibodies, Monoclonal • Antigens, CD20 • B-Lymphocytes • Child • Chronic Disease • Cord Blood Stem Cell Transplantation • Drug Therapy, Combination • Graft vs Host Disease • Humans • Male • Pemphigoid, Bullous • Receptors, Interleukin-2 • Treatment Outcome • administration & dosage* • adverse effects • drug effects • drug therapy* • immunology • pathology • therapeutic use