Publications [#80902] of Russell P. Hall III

Papers Published

1. RP Hall, TJ Lawley, JA Heck, SI Katz, IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases., Clinical and experimental immunology, ENGLAND, vol. 40 no. 3 (June, 1980), pp. 431-7, ISSN 0009-9104
   (last updated on 2007/03/27)

   Abstract:
   The sera of patients with dermatitis herpetiformis, Henoch-Schönlein purpura and systemic lupus erythematosus were examined for IgA-containing immune complexes using a newly described radioimmunoassay. The IgG Raji cell radioimmunoassay and the 125I-C1q binding assay were also used to detect IgG- and IgM- containing soluble immune complexes. IgA-containing immune complexes were found in the sera of twelve of forty-nine (24%) patients with dermatitis herpetiformis, four of six (67%) patients with Henoch-Schönlein purpura, and seven of ten (70%) patients with systemic lupus erythematosus. IgG- or IgM- containing immune complexes were also found in six of forty-seven patients with dermatitis herpetiformis, in one of six patients with Henoch-Schönlein purpura, and in nine of ten patients with systemic lupus erythematosus, by either the 125I-Clq binding assay or the IgG Raji cell assay. The finding of soluble IgA immune complexes in a high percentage of patients with systemic lupus erythematosus and Henoch-Schönlein purpura suggests that they may play an important role in the pathogenesis of these diseases. In contrast, their low prevalence in patients with dermatitis herpetiformis suggests that IgA-containing immune complexes may not play a major role in the pathogenesis of dermatitis herpetiformis.

   Keywords:
   Antigen-Antibody Complex* • Complement C3 • Dermatitis Herpetiformis • Female • Humans • Immunoglobulin A • Immunoglobulin G • Lupus Erythematosus, Systemic • Male • Purpura, Schoenlein-Henoch • Radioimmunoassay • Skin Diseases • analysis • immunology • immunology* • methods