Publications [#80908] of Russell P. Hall III

Papers Published

1. HH Kong, NS Prose, RE Ware, RP Hall 3rd, Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab)., Pediatric dermatology, vol. 22 no. 5 (February, 2006), pp. 461-4, ISSN 0736-8046 [doi]
   (last updated on 2013/05/13)

   Abstract:
   Pemphigus vulgaris is an uncommon autoimmune blistering skin disorder that is particularly rare in children. Immunosuppressive treatment can be challenging. Rituximab (anti-CD20 monoclonal antibody) has been used to treat autoimmune disorders by depletion of CD20 B cells. Successful rituximab therapy has been reported in adults with refractory pemphigus vulgaris. We present a girl with childhood pemphigus vulgaris unresponsive to treatment with azathioprine, mycophenolate mofetil, plasmapheresis, and intravenous immunoglobulin with systemic prednisone who responded to treatment with rituximab. She had a corresponding decline in circulating antibodies against desmoglein 1 and 3 and a decline in diphtheria and tetanus-specific antibody titers.

   Keywords:
   Adolescent • Antibodies, Monoclonal • Antibodies, Monoclonal, Murine-Derived • Antigens, CD20 • Female • Humans • Immunologic Factors • Immunosuppressive Agents • Pemphigus • Treatment Failure • Treatment Outcome • diagnosis • drug therapy* • immunology • therapeutic use • therapeutic use*