Publications [#338992] of Lawrence Carin

Papers Published

1. Dasgupta, N; Lin, S; Carin, L, Sequential modeling for identifying CpG island locations in human genome, IEEE Signal Processing Letters, vol. 9 no. 12 (December, 2002), pp. 407-409, Institute of Electrical and Electronics Engineers (IEEE) [LSP.2002.806062], [doi]
   (last updated on 2024/12/31)

   Abstract:
   We consider several sequential processing algorithms for identifying genes in human DNA, based on detecting CpG ("C proceeds G") islands. The algorithms are designed to capture the underlying statistical structure in a DNA sequence. Sequential processing using a Markov model and a hidden Markov model are shown to identify most CpG islands in annotated (marked) DNA subsequences available from publicly available DNA datasets. We also consider a wavelet-based hidden Markov tree (HMT). In the context of the HMT, we address design of adaptive wavelets matched to CpG islands, this accomplished via lifting and genetic-algorithm optimization.

   Keywords:
   Mathematical models;Genetic algorithms;Statistical methods;DNA sequences;Markov processes;Wavelet transforms;Trees (mathematics);Optimization;Time domain analysis;FIR filters;