Publications [#330232] of Michael J. Therien

Papers Published

1. Lau, CK; Bayly, CI; Gauthier, JY; Li, CS; Therien, M; Asante-Appiah, E; Cromlish, W; Boie, Y; Forghani, F; Desmarais, S; Wang, Q; Skorey, K; Waddleton, D; Payette, P; Ramachandran, C; Kennedy, BP; Scapin, G, Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors., Bioorganic & medicinal chemistry letters, vol. 14 no. 4 (February, 2004), pp. 1043-1048 [doi]
   (last updated on 2026/01/14)

   Abstract:
   A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.