Publications [#330234] of Michael J. Therien

Papers Published

1. Black, WC; Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Gordon, R; Grimm, EL; Hughes, G; Leger, S; Li, CS; Riendeau, D; Thérien, M; Wang, Z; Xu, LJ; Prasit, P, 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility., Bioorganic & medicinal chemistry letters, vol. 13 no. 6 (March, 2003), pp. 1195-1198 [doi]
   (last updated on 2026/01/16)

   Abstract:
   The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.