Publications [#330235] of Michael J. Therien

Papers Published

1. Li, CS; Brideau, C; Chan, CC; Savoie, C; Claveau, D; Charleson, S; Gordon, R; Greig, G; Gauthier, JY; Lau, CK; Riendeau, D; Thérien, M; Wong, E; Prasit, P, Pyridazinones as selective cyclooxygenase-2 inhibitors., Bioorganic & medicinal chemistry letters, vol. 13 no. 4 (February, 2003), pp. 597-600 [doi]
   (last updated on 2026/01/15)

   Abstract:
   Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.