Publications [#330246] of Michael J. Therien

Papers Published

1. Thérien, M; Brideau, C; Chan, CC; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Kargman, S; Lau, CK; Leblanc, Y; Li, CS; O'Neill, GP; Riendeau, D; Roy, P; Wang, Z; Xu, L; Prasit, P, Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors, Bioorganic and Medicinal Chemistry Letters, vol. 7 no. 1 (January, 1997), pp. 47-52, Elsevier BV [doi]
   (last updated on 2026/01/15)

   Abstract:
   A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.