Publications [#330258] of Michael J. Therien

Papers Published

1. Gauthier, JY; Henien, T; Lo, L; Thérien, M; Young, RN, A novel and efficient method for the preparation of asymmetric dithioacetals, Tetrahedron Letters, vol. 29 no. 51 (January, 1988), pp. 6729-6732, Elsevier BV [doi]
   (last updated on 2026/01/14)

   Abstract:
   Aldehydes and ketones react with one equivalent each of thiols and thiolacetic acid under acid catalysis to yield almost exclusively the mixed alkylthio-(or arylthio-) acylthioacetals. Reaction of the mixed thioacetal with a nucleophile (such as NaOMe) liberates the thiolate anion which can be trapped with a variety of electrophiles to provide asymmetric dithioacetals in high yields. © 1988.