Publications [#199986] of Nathan M Thielman

Papers Published

1. KO Saunders, C Ward-Caviness, RJ Schutte, SA Freel, RG Overman, NM Thielman, CK Cunningham, TB Kepler, GD Tomaras, Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage., Cellular immunology, vol. 266 no. 2 (2011), pp. 154-64, ISSN 1090-2163 [doi]
   (last updated on 2011/12/18)

   Abstract:
   CD8(+) T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p<0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication.

   Keywords:
   Acetylation • CD8-Positive T-Lymphocytes • Chemokine CCL3 • Chemokine CCL4 • Chemokine CXCL10 • Down-Regulation • Gene Expression • HIV Infections • HIV-1 • Histones • Humans • Interferon-gamma • Up-Regulation • Valproic Acid • Virus Replication • immunology • immunology* • metabolism • metabolism*