| Publications [#132188] of James M Provenzale
Papers Published
- JM Provenzale, S Mukundan, M Dewhirst, The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.,
AJR. American journal of roentgenology, vol. 185 no. 3
(September, 2005),
pp. 763-7, ISSN 0361-803X [doi]
(last updated on 2013/05/16)
Abstract: OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
Keywords: Animals • Biological Transport • Blood-Brain Barrier • Brain Neoplasms • Contrast Media • Humans • Magnetic Resonance Imaging* • Neovascularization, Pathologic • Permeability • diagnosis • diagnosis* • physiology* • physiopathology • therapy • therapy*
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