Publications [#132215] of James M Provenzale

Papers Published

1. KR Krishnan, WD Taylor, DR McQuoid, JR MacFall, ME Payne, JM Provenzale, DC Steffens, Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression., Biological psychiatry, United States, vol. 55 no. 4 (February, 2004), pp. 390-7, ISSN 0006-3223
   (last updated on 2007/02/06)

   Abstract:
   BACKGROUND: There is a substantial body of research supporting the vascular depression hypothesis of late-life depression. To update this hypothesis so it incorporates recent research, we propose that the term subcortical ischemic vascular depression may be a more accurate representation of the disease process. We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression. METHODS: This case-control study examined 139 depressed elderly subjects. Demographic data, psychiatric, medical, and family history, depressive symptomatology, and functional impairment were compared between groups dichotomized based on neuroimaging findings. RESULTS: Seventy-five (54%) of the subjects met neuroimaging criteria for subcortical ischemic vascular depression. Age was most strongly associated with increased prevalence of subcortical ischemic vascular depression. Lassitude and a history of hypertension were also positively associated with the diagnosis; a family history of mental illness and loss of libido were negatively associated with the diagnosis. CONCLUSIONS: These data support that subcortical ischemic vascular depression may be a specific syndrome from other types of late-life depression. Further research is needed to further characterize this disorder, particularly in regards to cognitive function and treatment implications.

   Keywords:
   Age Factors • Age of Onset • Aged • Aged, 80 and over • Antidepressive Agents • Brain Ischemia • Case-Control Studies • Chi-Square Distribution • Cognition • Cognition Disorders • Demography • Depression • Female • Geriatric Assessment • Humans • Logistic Models • Longitudinal Studies • Magnetic Resonance Imaging* • Male • Middle Aged • Psychiatric Status Rating Scales • Severity of Illness Index • complications* • diagnosis • diagnosis* • drug therapy • epidemiology • etiology • physiology • therapeutic use