Publications [#237011] of John H. Reif

Journal articles or Book chapters PUBLISHED

1. Yin, P; Turberfield, AJ; Reif, JH, Designs of autonomous unidirectional walking DNA devices, Lecture Notes in Computer Science, vol. 3384 (January, 2005), pp. 410-425 [doi]
   (last updated on 2026/01/14)

   Abstract:
   Imagine a host of nanoscale DNA robots move autonomously over a microscale DNA nanostructure, each following a programmable route and serving as a nanoparticle and/or an information carrier. The accomplishment of this goal has many applications in nanorobotics, nano-fabrication, nano-electronics, nano-diagnostics/therapeutics, and nano-computing. Recent success in constructing large scale DNA nanostructures in a programmable way provides the structural basis to meet the above challenge. The missing link is a DNA walker that can autonomously move along a route programmably embedded in the under-lying nanostructure - existing synthetic DNA mechanical devices only exhibit localized non-extensible motions such as bi-directional rotation, open/close, and contraction/extension, mediated by external environmental changes. We describe in this paper two designs of autonomous DNA walking devices in which a walker moves along a linear track unidirectionally. The track of each device consists of a periodic linear array of anchorage sites. A walker sequentially steps over the anchorages in an autonomous unidirectional way. Each walking device makes use of alternating actions of restriction enzymes and ligase to achieve unidirectional translational motion. © Springer-Verlag Berlin Heidelberg 2005.